Leucovorin for Autism
What is behind the US government's announcement?
Currently, only the antidepressants Risperidone and Aripiprazole are approved in the US for the treatment of autism spectrum disorders (ASD).
On 22 September, US President Trump, US Secretary of Health and Human Service Robert F. Kennedy Jr. and senior US Food and Drug Administration (FDA) officials caused some concern among parents of autistic children with their announcements regarding the side effects of Tylenol and leucovorin.
What findings are available and what should one know about them?
Prof. Dr. Richard E. Frye, autism researcher and treating physician, has been studying leucovorin and its potential for treating ASD for 20 years.
In a press release dated 1 October 2025, he gives a detailed account of what we know and what potential can be expected from leucovorin.